Adenosine 3':5'-monophosphate content and actions in the division cycle of synchronized HeLa cells.
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Adenosine 3':5'-monophosphate content and actions in the division cycle of synchronized HeLa cells
The involvement of adenosine 3':5'-monophosphate (cAMP) in the regulation of the cell cycle was studied by determining intracellular fluctuations in cAMP levels in synchronized HeLa cells and by testing the effects of experimentally altered levels on cell cycle traverse. Cyclic AMP levels were lowest during mitosis and were highest during late G-1 or early S phase. These findings were supported...
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Progression of the HeLa cell through its life cycle is accompanied by centriolar replication and pericentriolar changes that are in synchrony with DNA synthesis and mitosis. The first signs of preparation for replication occur during G(1) at which time the two orthogonal centrioles separate. Replication by budding begins at/or near the initiation of DNA synthesis and is completed by G(2). Peric...
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ژورنال
عنوان ژورنال: Journal of Cell Biology
سال: 1976
ISSN: 0021-9525,1540-8140
DOI: 10.1083/jcb.71.2.515